Role of tautomerism in RNA biochemistry

Heterocyclic nucleic acid bases and their analogs can adopt multiple tautomeric forms due to the presence of multiple solvent-exchangeable protons. In DNA, spontaneous formation of minor tautomers has been speculated to contribute to mutagenic mispairings during DNA replication, whereas in RNA, mino...

Full description

Bibliographic Details
Main Authors: Singh, Vipender, Fedeles, Bogdan I., Essigmann, John M.
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press 2014
Online Access:http://hdl.handle.net/1721.1/92497
https://orcid.org/0000-0002-8241-4834
https://orcid.org/0000-0002-2196-5691