Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

Succinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both the electron transport chain and the citric acid cycle. SDH mutations resulting in enzymatic dysfunction have been found to be a predisposing factor in various hereditary cancers. Therefore, SDH has been impli...

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Bibliographic Details
Main Authors: Aspuria, Paul-Joseph P., Lunt, Sophia Yunkyungkwon, Väremo, Leif, Vergnes, Laurent, Gozo, Maricel, Beach, Jessica A, Salumbides, Brenda, Reue, Karen, Wiedemeyer, W. R., Nielsen, Jens Kromann, Karlan, Beth Y., Orsulic, Sandra
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: BioMed Central Ltd. 2014
Online Access:http://hdl.handle.net/1721.1/92499

Internet

http://hdl.handle.net/1721.1/92499

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