Multi-input CRISPR/Cas genetic circuits that interface host regulatory networks
Genetic circuits require many regulatory parts in order to implement signal processing or execute algorithms in cells. A potentially scalable approach is to use dCas9, which employs small guide RNAs (sgRNAs) to repress genetic loci via the programmability of RNA:DNA base pairing. To this end, we use...
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| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2014
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| Online Access: | http://hdl.handle.net/1721.1/92529 https://orcid.org/0000-0003-0844-4776 https://orcid.org/0000-0003-2171-8460 |