MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

We propose the Model-based Analysis of Genome-wide CRISPR/Cas9 Knockout (MAGeCK) method for prioritizing single-guide RNAs, genes and pathways in genome-scale CRISPR/Cas9 knockout screens. MAGeCK demonstrates better performance compared with existing methods, identifies both positively and negativel...

Full description

Bibliographic Details
Main Authors: Li, Wei, Xu, Han, Xiao, Tengfei, Cong, Le, Love, Michael I., Zhang, Feng, Irizarry, Rafael A., Liu, Jun S., Brown, Myles, Liu, X. Shirley
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: BioMed Central Ltd 2015
Online Access:http://hdl.handle.net/1721.1/92852
https://orcid.org/0000-0003-2782-2509

Internet

http://hdl.handle.net/1721.1/92852
https://orcid.org/0000-0003-2782-2509

Similar Items