β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome

 β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome

Rett syndrome is a severe childhood onset neurodevelopmental disorder caused by mutations in methyl-CpG–binding protein 2 (MECP2), with known disturbances in catecholamine synthesis. Here, we show that treatment with the β2-adrenergic receptor agonist clenbuterol increases survival, rescues abnormal...

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Bibliographic Details
Main Authors: Mellios, Nikolaos, Woodson, Jonathan, Garcia, Rodrigo, Crawford, Benjamin, Sharma, Jitendra, Sheridan, Steven, Sur, Mriganka, Haggarty, Stephen J.
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2015
Online Access:http://hdl.handle.net/1721.1/93783
https://orcid.org/0000-0003-2442-5671
https://orcid.org/0000-0001-9403-8787
https://orcid.org/0000-0002-3551-1244

Internet

http://hdl.handle.net/1721.1/93783
https://orcid.org/0000-0003-2442-5671
https://orcid.org/0000-0001-9403-8787
https://orcid.org/0000-0002-3551-1244

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