Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine

Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine

Viral lethal mutagenesis is a strategy whereby the innate immune system or mutagenic pool nucleotides increase the error rate of viral replication above the error catastrophe limit. Lethal mutagenesis has been proposed as a mechanism for several antiviral compounds, including the drug candidate 5-az...

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Bibliographic Details
Main Authors: Li, Deyu, Fedeles, Bogdan I., Singh, Vipender, Peng, Chunte Sam, Silvestre, Katherine J., Simi, Allison K., Simpson, Jeffrey H., Essigmann, John M., Tokmakoff, Andrei
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2015
Online Access:http://hdl.handle.net/1721.1/93785
https://orcid.org/0000-0002-8241-4834
https://orcid.org/0000-0002-2196-5691

Internet

http://hdl.handle.net/1721.1/93785
https://orcid.org/0000-0002-8241-4834
https://orcid.org/0000-0002-2196-5691

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