Synthesis of Solid 2-Pyridylzinc Reagents and Their Application in Negishi Reactions

In search of alternatives to unstable or unreliable 2-pyridylboron reagents, we have explored two new varieties of solid, moderately air-stable 2-pyridylzinc reagents. Both reagents can be manipulated in air and are competent nucleophiles in Negishi cross-coupling reactions.

Bibliographic Details
Main Authors: Bernhardt, Sebastian, Stathakis, Christos, Knochel, Paul, Colombe, James Robert, Buchwald, Stephen Leffler
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2015
Online Access:http://hdl.handle.net/1721.1/94497
https://orcid.org/0000-0002-8750-7968
https://orcid.org/0000-0003-3875-4775