Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism

Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism

7-carboxy-7-deazaguanine synthase (QueE) catalyzes a key S-adenosyl-L-methionine (AdoMet)- and Mg[superscript 2+]-dependent radical-mediated ring contraction step, which is common to the biosynthetic pathways of all deazapurine-containing compounds. QueE is a member of the AdoMet radical superfamily...

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Bibliographic Details
Main Authors: Bruender, Nathan A, Young, Anthony P, McCarty, Reid M, Bandarian, Vahe, Dowling, Daniel P., Drennan, Catherine L
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/94563
https://orcid.org/0000-0001-5486-2755

Internet

http://hdl.handle.net/1721.1/94563
https://orcid.org/0000-0001-5486-2755

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