Dynamic Nuclear Polarization Study of Inhibitor Binding to the M2[subscript 18–60] Proton Transporter from Influenza A

Dynamic Nuclear Polarization Study of Inhibitor Binding to the M2[subscript 18–60] Proton Transporter from Influenza A

We demonstrate the use of dynamic nuclear polarization (DNP) to elucidate ligand binding to a membrane protein using dipolar recoupling magic angle spinning (MAS) NMR. In particular, we detect drug binding in the proton transporter M2[subscript 18–60] from influenza A using recoupling experiments at...

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Bibliographic Details
Main Authors: Andreas, Loren, Barnes, Alexander, Chou, James J., Caporini, Marc A., Rosay, Melanie, Corzilius, Bjorn, Miller, Eric Alexander, Griffin, Robert Guy
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2015
Online Access:http://hdl.handle.net/1721.1/94619
https://orcid.org/0000-0003-1589-832X
https://orcid.org/0000-0002-6217-3922

Internet

http://hdl.handle.net/1721.1/94619
https://orcid.org/0000-0003-1589-832X
https://orcid.org/0000-0002-6217-3922

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