Synergistic cytotoxicity of irinotecan and cisplatin in dual-drug targeted polymeric nanoparticles
Aim: Two unexplored aspects for irinotecan and cisplatin (I&C) combination chemotherapy are: actively targeting both drugs to a specific diseased cell type, and delivering both drugs on the same vehicle to ensure their synchronized entry into the cell at a well-defined ratio. In this work, the a...
Main Authors: | Valencia, Pedro M, Pridgen, Eric M, Perea, Brian, Gadde, Suresh, Sweeney, Christopher, Kantoff, Philip W., Bander, Neil H., Langer, Robert, Lippard, Stephen J., Farokhzad, Omid C., Karnik, Rohit, Valencia, Pedro M., Pridgen, Eric M. |
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Other Authors: | MIT-Harvard Center for Cancer Nanotechnology Excellence |
Format: | Article |
Language: | en_US |
Published: |
Future Medicine
2015
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Online Access: | http://hdl.handle.net/1721.1/95422 https://orcid.org/0000-0003-0588-9286 https://orcid.org/0000-0002-2693-4982 https://orcid.org/0000-0002-2640-3006 https://orcid.org/0000-0003-4255-0492 |
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