Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent

Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent

An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemothera...

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Bibliographic Details
Main Authors: Wisnovsky, Simon P., Wilson, Justin J., Radford, Robert J., Pereira, Mark P., Chan, Maria R., Laposa, Rebecca R., Lippard, Stephen J., Kelley, Shana O.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/95474
https://orcid.org/0000-0002-2693-4982

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http://hdl.handle.net/1721.1/95474
https://orcid.org/0000-0002-2693-4982

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