Conjugation of vitamin E analog α-TOS to Pt(IV) complexes for dual-targeting anticancer therapy
We report two platinum(IV) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and α-TOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as a promising dual-targetin...
| Main Authors: | , , |
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| Andre forfattere: | |
| Format: | Article |
| Sprog: | en_US |
| Udgivet: |
Royal Society of Chemistry
2015
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| Online adgang: | http://hdl.handle.net/1721.1/95497 https://orcid.org/0000-0002-2693-4982 |