Contributions of the S100A9 C-Terminal Tail to High-Affinity Mn(II) Chelation by the Host-Defense Protein Human Calprotectin

Contributions of the S100A9 C-Terminal Tail to High-Affinity Mn(II) Chelation by the Host-Defense Protein Human Calprotectin

Human calprotectin (CP) is an antimicrobial protein that coordinates Mn(II) with high affinity in a Ca(II)-dependent manner at an unusual histidine-rich site (site 2) formed at the S100A8/S100A9 dimer interface. We present a 16-member CP mutant family where mutations in the S100A9 C-terminal tail (r...

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Bibliographic Details
Main Authors: Nolan, Elizabeth M., Brophy, Megan Brunjes, Nakashige, Toshiki George, Gaillard de Saint Germain, Aleth
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2015
Online Access:http://hdl.handle.net/1721.1/95514
https://orcid.org/0000-0002-6153-8803
https://orcid.org/0000-0001-9179-7972
https://orcid.org/0000-0002-6234-8155

Internet

http://hdl.handle.net/1721.1/95514
https://orcid.org/0000-0002-6153-8803
https://orcid.org/0000-0001-9179-7972
https://orcid.org/0000-0002-6234-8155

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