Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1

Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1

Expansions of preexisting polyglutamine (polyQ) tracts in at least nine different proteins cause devastating neurodegenerative diseases. There are many unique features to these pathologies, but there must also be unifying mechanisms underlying polyQ toxicity. Using a polyQ-expanded fragment of hunti...

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Bibliographic Details
Main Authors: Hesse, William R., Shah, Jagesh Vijaykumar, Kayatekin, Can, Matlack, Kent E. S., Guan, Yinghua, Chakrabortee, Sohini, Russ, Jenny, Wanker, Erich E., Lindquist, Susan
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2015
Online Access:http://hdl.handle.net/1721.1/95753
https://orcid.org/0000-0003-1307-882X
https://orcid.org/0000-0002-3759-2500

Internet

http://hdl.handle.net/1721.1/95753
https://orcid.org/0000-0003-1307-882X
https://orcid.org/0000-0002-3759-2500

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