Threonine 149 Phosphorylation Enhances  ΔFosB Transcriptional Activity to Control Psychomotor Responses to Cocaine

Threonine 149 Phosphorylation Enhances  ΔFosB Transcriptional Activity to Control Psychomotor Responses to Cocaine

Stable changes in neuronal gene expression have been studied as mediators of addicted states. Of particular interest is the transcription factor ΔFosB, a truncated and stable FosB gene product whose expression in nucleus accumbens (NAc), a key reward region, is induced by chronic exposure to virtual...

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Bibliographic Details
Main Authors: Neve, Rachael L., Cates, Hannah M., Thibault, Mackenzie, Pfau, Madeline, Heller, Elizabeth, Eagle, Andrew, Gajewski, Paula, Bagot, Rosemary, Colangelo, Christopher, Abbott, Thomas, Rudenko, Gabby, Nestler, Eric J., Robinson, Alfred J.
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Society for Neuroscience 2015
Online Access:http://hdl.handle.net/1721.1/95796
https://orcid.org/0000-0002-3854-5968

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