Reprogramming Factor Stoichiometry Influences the Epigenetic State and Biological Properties of Induced Pluripotent Stem Cells

Reprogramming Factor Stoichiometry Influences the Epigenetic State and Biological Properties of Induced Pluripotent Stem Cells

We compared two genetically highly defined transgenic systems to identify parameters affecting reprogramming of somatic cells to a pluripotent state. Our results demonstrate that the level and stoichiometry of reprogramming factors during the reprogramming process strongly influence the resulting pl...

Full description

Bibliographic Details
Main Authors: Carey, Bryce W., Markoulaki, Styliani, Hanna, Jacob, Faddah, Dina A., Buganim, Yosef, Kim, Jongpil, Ganz, Kibibi, Steine, Eveline J., Cassady, John P., Creyghton, Menno P., Welstead, G. Grant, Gao, Qing, Jaenisch, Rudolf
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/95810

Internet

http://hdl.handle.net/1721.1/95810

Similar Items