Engineering Enzyme Specificity Using Computational Design of a Defined-Sequence Library

Engineering Enzyme Specificity Using Computational Design of a Defined-Sequence Library

Engineered biosynthetic pathways have the potential to produce high-value molecules from inexpensive feedstocks, but a key limitation is engineering enzymes with high activity and specificity for new reactions. Here, we developed a method for combining structure-based computational protein design wi...

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Bibliographic Details
Main Authors: Lippow, Shaun M., Moon, Tae Seok, Basu, Subhayu, Yoon, Sang-Hwal, Li, Xiazhen, Chapman, Brad A., Robison, Keith, Lipovšek, Daša, Prather, Kristala L. Jones
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/96044
https://orcid.org/0000-0003-0437-3157

Internet

http://hdl.handle.net/1721.1/96044
https://orcid.org/0000-0003-0437-3157

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