Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues

Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic expression of defined transcription factors has raised fundamental questions regarding the epigenetic stability of the differentiated cell state. In addition, evidence has accumulated that distinct states of pluripote...

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Bibliographic Details
Main Authors: Hanna, Jacob, Saha, Krishanu, Jaenisch, Rudolf
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier B.V. 2015
Online Access:http://hdl.handle.net/1721.1/96107