Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
The large serine/threonine protein kinase mTOR regulates cellular and organismal homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and oxygen availability and growth factor signaling. Cells and organisms experience a wide variety of insults that perturb the homeosta...
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| Formato: | Artigo |
| Idioma: | en_US |
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Elsevier B.V.
2015
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| Acesso em linha: | http://hdl.handle.net/1721.1/96111 https://orcid.org/0000-0002-1446-7256 |
| _version_ | 1826205411090366464 |
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| author | Sengupta, Shomit Peterson, Timothy Richard Sabatini, David |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Sengupta, Shomit Peterson, Timothy Richard Sabatini, David |
| author_sort | Sengupta, Shomit |
| collection | MIT |
| description | The large serine/threonine protein kinase mTOR regulates cellular and organismal homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and oxygen availability and growth factor signaling. Cells and organisms experience a wide variety of insults that perturb the homeostatic systems governed by mTOR and therefore require appropriate stress responses to allow cells to continue to function. Stress can manifest from an excess or lack of upstream signals or as a result of genetic perturbations in upstream effectors of the pathway. mTOR nucleates two large protein complexes that are important nodes in the pathways that help buffer cells from stresses, and are implicated in the progression of stress-associated phenotypes and diseases, such as aging, tumorigenesis, and diabetes. This review focuses on the key components of the mTOR complex 1 pathway and on how various stresses impinge upon them. |
| first_indexed | 2024-09-23T13:12:15Z |
| format | Article |
| id | mit-1721.1/96111 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:12:15Z |
| publishDate | 2015 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/961112022-10-01T13:44:41Z Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress Sengupta, Shomit Peterson, Timothy Richard Sabatini, David Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Koch Institute for Integrative Cancer Research at MIT Sengupta, Shomit Peterson, Timothy R. Sabatini, David M. The large serine/threonine protein kinase mTOR regulates cellular and organismal homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and oxygen availability and growth factor signaling. Cells and organisms experience a wide variety of insults that perturb the homeostatic systems governed by mTOR and therefore require appropriate stress responses to allow cells to continue to function. Stress can manifest from an excess or lack of upstream signals or as a result of genetic perturbations in upstream effectors of the pathway. mTOR nucleates two large protein complexes that are important nodes in the pathways that help buffer cells from stresses, and are implicated in the progression of stress-associated phenotypes and diseases, such as aging, tumorigenesis, and diabetes. This review focuses on the key components of the mTOR complex 1 pathway and on how various stresses impinge upon them. 2015-03-20T14:33:33Z 2015-03-20T14:33:33Z 2010-10 Article http://purl.org/eprint/type/JournalArticle 10972765 http://hdl.handle.net/1721.1/96111 Sengupta, Shomit, Timothy R. Peterson, and David M. Sabatini. “Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress.” Molecular Cell 40, no. 2 (October 2010): 310–322. © 2010 Elsevier Inc. https://orcid.org/0000-0002-1446-7256 en_US http://dx.doi.org/10.1016/j.molcel.2010.09.026 Molecular Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier B.V. Elsevier |
| spellingShingle | Sengupta, Shomit Peterson, Timothy Richard Sabatini, David Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress |
| title | Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress |
| title_full | Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress |
| title_fullStr | Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress |
| title_full_unstemmed | Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress |
| title_short | Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress |
| title_sort | regulation of the mtor complex 1 pathway by nutrients growth factors and stress |
| url | http://hdl.handle.net/1721.1/96111 https://orcid.org/0000-0002-1446-7256 |
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