Synthetic shuffling and in vitro selection reveal the rugged adaptive fitness landscape of a kinase ribozyme

The relationship between genotype and phenotype is often described as an adaptive fitness landscape. In this study, we used a combination of recombination, in vitro selection, and comparative sequence analysis to characterize the fitness landscape of a previously isolated kinase ribozyme. Point muta...

Повний опис

Бібліографічні деталі
Автори: Bartel, David, Curtis, Edward A.
Інші автори: Massachusetts Institute of Technology. Department of Biology
Формат: Стаття
Мова:en_US
Опубліковано: Cold Spring Harbor Laboratory Press 2015
Онлайн доступ:http://hdl.handle.net/1721.1/96216
https://orcid.org/0000-0002-3872-2856