De novo design of a transmembrane Zn[superscript 2+]-transporting four-helix bundle

De novo design of a transmembrane Zn[superscript 2+]-transporting four-helix bundle

The design of functional membrane proteins from first principles represents a grand challenge in chemistry and structural biology. Here, we report the design of a membrane-spanning, four-helical bundle that transports first-row transition metal ions Zn[superscript 2+] and Co[superscript 2+], but not...

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Bibliographic Details
Main Authors: Wang, Tuo, Hong, Mei, Joh, Nathan H., Bhate, Manasi P., Acharya, Rudresh, Wu, Yibing, Grabe, Michael, Grigoryan, Gevorg, DeGrado, William F.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2015
Online Access:http://hdl.handle.net/1721.1/96253
https://orcid.org/0000-0002-1801-924X
https://orcid.org/0000-0001-5255-5858

Internet

http://hdl.handle.net/1721.1/96253
https://orcid.org/0000-0002-1801-924X
https://orcid.org/0000-0001-5255-5858

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