OMP Peptides Activate the DegS Stress-Sensor Protease by a Relief of Inhibition Mechanism
In the E. coli periplasm, C-terminal peptides of misfolded outer-membrane porins (OMPs) bind to the PDZ domains of the trimeric DegS protease, triggering cleavage of a transmembrane regulator and transcriptional activation of stress genes. We show that an active-site DegS mutation partially bypasses...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier B.V.
2015
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| Online Access: | http://hdl.handle.net/1721.1/96266 https://orcid.org/0000-0002-1719-5399 |