Computational design of a red fluorophore ligase for site-specific protein labeling in living cells

Computational design of a red fluorophore ligase for site-specific protein labeling in living cells

Chemical fluorophores offer tremendous size and photophysical advantages over fluorescent proteins but are much more challenging to target to specific cellular proteins. Here, we used Rosetta-based computation to design a fluorophore ligase that accepts the red dye resorufin, starting from Escherich...

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Bibliographic Details
Main Authors: Baker, David, Ting, Alice Y., Liu, Daniel S., Nivon, Lucas G., Richter, Florian, Goldman, Peter J., Yao, Jennifer Z., Phipps, William S., Ye, Anne Z., Deerinck, Thomas J., Richardson, Douglas, Ellisman, Mark H., Drennan, Catherine L
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2015
Online Access:http://hdl.handle.net/1721.1/96304
https://orcid.org/0000-0001-5486-2755
https://orcid.org/0000-0002-8277-5226

Internet

http://hdl.handle.net/1721.1/96304
https://orcid.org/0000-0001-5486-2755
https://orcid.org/0000-0002-8277-5226

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