Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

Whole-chromosome copy number alterations, also known as aneuploidy, are associated with adverse consequences in most cells and organisms. However, high frequencies of aneuploidy have been reported to occur naturally in the mammalian liver and brain, fueling speculation that aneuploidy provides a sel...

Full description

Bibliographic Details
Main Authors: Wu, Jie, Whittaker, Charles A., Knouse, Kristin Ann, Amon, Angelika B
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2015
Online Access:http://hdl.handle.net/1721.1/96316
https://orcid.org/0000-0002-0989-8115
https://orcid.org/0000-0001-9837-0314
https://orcid.org/0000-0003-0649-7428