Symmetric Signaling by an Asymmetric 1 Erythropoietin: 2 Erythropoietin Receptor Complex

Symmetric Signaling by an Asymmetric 1 Erythropoietin: 2 Erythropoietin Receptor Complex

Via sites 1 and 2, erythropoietin binds asymmetrically to two identical receptor monomers, although it is unclear how asymmetry affects receptor activation and signaling. Here we report the design and validation of two mutant erythropoietin receptors that probe the role of individual members of the...

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Bibliographic Details
Main Authors: Zhang, Yingxin L., Radhakrishnan, Mala L., Lu, Xiaohui, Gross, Alec W., Tidor, Bruce, Lodish, Harvey F
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/96330
https://orcid.org/0000-0002-3320-3969
https://orcid.org/0000-0002-7029-7415

Internet

http://hdl.handle.net/1721.1/96330
https://orcid.org/0000-0002-3320-3969
https://orcid.org/0000-0002-7029-7415

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