Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

Sirtuin 1 (Sirt1), a NAD[superscript +]-regulated deacetylase with numerous known positive effects on cellular and whole-body metabolism, is expressed in the renal cortex and medulla. It is known to have protective effects against age-related disease, including diabetes. Here we investigated the pro...

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Bibliographic Details
Main Authors: Hasegawa, Kazuhiro, Wakino, Shu, Simic, Petra, Sakamaki, Yusuke, Minakuchi, Hitoshi, Fujimura, Keiko, Hosoya, Kozi, Komatsu, Motoaki, Kaneko, Yuka, Kanda, Takeshi, Kubota, Eiji, Tokuyama, Hirobumi, Itoh, Hiroshi, Guarente, Leonard Pershing, Hayashi, Koichi, 1967-
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/96409
https://orcid.org/0000-0003-4064-2510

Internet

http://hdl.handle.net/1721.1/96409
https://orcid.org/0000-0003-4064-2510

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