Tailoring Chimeric Ligands for Studying and Biasing ErbB Receptor Family Interactions
Described is the development and application of a versatile semisynthetic strategy, based on a combination of sortase-mediated coupling and tetrazine ligation chemistry, which can be exploited for the efficient incorporation of tunable functionality into chimeric recombinant proteins. To demonstrate...
Main Authors: | Krueger, Andrew T., Kroll, Carsten, Sanchez, Edgar, Imperiali, Barbara, Griffith, Linda G |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | en_US |
Published: |
Wiley Blackwell
2015
|
Online Access: | http://hdl.handle.net/1721.1/96496 https://orcid.org/0000-0002-5749-7869 https://orcid.org/0000-0002-1801-5548 |
Similar Items
-
Engineered Bivalent Ligands to Bias ErbB Receptor-mediated Signaling and Phenotypes
by: Jay, Steven M., et al.
Published: (2012) -
Differences in the binding affinities of ErbB family : heterogeneity in the prediction of resistance mutants
by: Verma, Chandra S., et al.
Published: (2014) -
Computational modeling of ErbB kinase oligomeric state.
by: Lim, Sing Mei.
Published: (2010) -
Expression of c-erbB3 protein in primary breast carcinomas.
by: Naidu, R., et al.
Published: (1998) -
Quantitative modeling perspectives on the ErbB system of cell regulatory processes
by: Lazzara, Matthew J., et al.
Published: (2010)