Ligand-Controlled Asymmetric Arylation of Aliphatic α-Amino Anion Equivalents

A palladium-catalyzed asymmetric arylation of 9-aminofluorene-derived imines using a chiral dialkylbiaryl phosphine as the supporting ligand has been developed. This transformation allows for enantioselective access to a diverse range of α-branched benzylamines.

Bibliographic Details
Main Authors: Zhu, Ye, Buchwald, Stephen Leffler
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2015
Online Access:http://hdl.handle.net/1721.1/96508
https://orcid.org/0000-0002-8566-576X
https://orcid.org/0000-0003-3875-4775