Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

Genome-wide characterization of the in vivo cellular response to perturbation is fundamental to understanding how cells survive stress. Identifying the proteins and pathways perturbed by small molecules affects biology and medicine by revealing the mechanisms of drug action. We used a yeast chemogen...

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Bibliographic Details
Main Authors: Spear, Eric D., Kaiser, Chris
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2015
Online Access:http://hdl.handle.net/1721.1/96521
https://orcid.org/0000-0002-1505-0479