Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

Genome-wide characterization of the in vivo cellular response to perturbation is fundamental to understanding how cells survive stress. Identifying the proteins and pathways perturbed by small molecules affects biology and medicine by revealing the mechanisms of drug action. We used a yeast chemogen...

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Detalhes bibliográficos
Principais autores: Spear, Eric D., Kaiser, Chris
Outros Autores: Massachusetts Institute of Technology. Department of Biology
Formato: Artigo
Idioma:en_US
Publicado em: American Association for the Advancement of Science (AAAS) 2015
Acesso em linha:http://hdl.handle.net/1721.1/96521
https://orcid.org/0000-0002-1505-0479