Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

Bacterial type II CRISPR-Cas9 systems have been widely adapted for RNA-guided genome editing and transcription regulation in eukaryotic cells, yet their in vivo target specificity is poorly understood. Here we mapped genome-wide binding sites of a catalytically inactive Cas9 (dCas9) from Streptococc...

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Bibliographic Details
Main Authors: Wu, Xuebing, Cheng, Albert W., Chen, Sidi, Jaenisch, Rudolf, Zhang, Feng, Chiu, Anthony Chun-yin, Sharp, Phillip A., Scott, David Arthur, Hsu, Patrick, Trevino, Alexandro E., Kriz, Andrea J., Dadon, Daniel Benjamin, Konermann, Silvana M
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/96524
https://orcid.org/0000-0003-2782-2509
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0001-7915-1685
https://orcid.org/0000-0002-7256-3158
https://orcid.org/0000-0002-0187-6800
https://orcid.org/0000-0002-2639-9879
https://orcid.org/0000-0003-0369-5269

Internet

http://hdl.handle.net/1721.1/96524
https://orcid.org/0000-0003-2782-2509
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0001-7915-1685
https://orcid.org/0000-0002-7256-3158
https://orcid.org/0000-0002-0187-6800
https://orcid.org/0000-0002-2639-9879
https://orcid.org/0000-0003-0369-5269

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