Negative Self-Regulation of TLR9 Signaling by Its N-Terminal Proteolytic Cleavage Product
TLR signaling is essential to innate immunity against microbial invaders and must be tightly controlled. We have previously shown that TLR9 undergoes proteolytic cleavage processing by lysosomal proteases to generate two distinct fragments. The C-terminal cleavage product plays a critical role in ac...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Association of Immunologists
2015
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| Online Access: | http://hdl.handle.net/1721.1/96698 https://orcid.org/0000-0002-1090-6071 |