Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes, and epigenetic states, but current models do not adequately reflect tumor composition in patients. We used single-cell RNA sequencing (RNA-seq) to profile 430 cells from five primary glioblastomas, which we f...

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Bibliographic Details
Main Authors: Patel, A. P., Tirosh, I., Trombetta, J. J., Gillespie, S. M., Wakimoto, H., Cahill, D. P., Nahed, B. V., Curry, W. T., Martuza, R. L., Louis, D. N., Rozenblatt-Rosen, O., Suva, M. L., Bernstein, Bradley E., Regev, Aviv, Shalek, Alex K.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2015
Online Access:http://hdl.handle.net/1721.1/96704
https://orcid.org/0000-0001-8567-2049

Internet

http://hdl.handle.net/1721.1/96704
https://orcid.org/0000-0001-8567-2049

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