Toward More Accurate Ancestral Protein Genotype-Phenotype Reconstructions with the Use of Species Tree-Aware Gene Trees

Toward More Accurate Ancestral Protein Genotype-Phenotype Reconstructions with the Use of Species Tree-Aware Gene Trees

The resurrection of ancestral proteins provides direct insight into how natural selection has shaped proteins found in nature. By tracing substitutions along a gene phylogeny, ancestral proteins can be reconstructed in silico and subsequently synthesized in vitro. This elegant strategy reveals the c...

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Bibliographic Details
Main Authors: Groussin, Mathieu, Hobbs, Joanne K., Szöllősi, Gergely J., Gribaldo, Simonetta, Arcus, Vickery L., Gouy, Manolo
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Oxford University Press 2015
Online Access:http://hdl.handle.net/1721.1/96705
https://orcid.org/0000-0002-0942-7217

Internet

http://hdl.handle.net/1721.1/96705
https://orcid.org/0000-0002-0942-7217

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