Mechanochemical basis of protein degradation by a double-ring AAA+ machine

Molecular machines containing double or single AAA+ rings power energy-dependent protein degradation and other critical cellular processes, including disaggregation and remodeling of macromolecular complexes. How the mechanical activities of double-ring and single-ring AAA+ enzymes differ is unknown...

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Bibliographic Details
Main Authors: Iosefson, Ohad, Olivares, Adrian O., Baker, Tania, Nager, Andrew Ross, Sauer, Robert T
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/96709
https://orcid.org/0000-0003-1710-9582
https://orcid.org/0000-0002-1719-5399