Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

Genome sequencing studies have shown that human malignancies often bear mutations in four or more driver genes[superscript 1], but it is difficult to recapitulate this degree of genetic complexity in mouse models using conventional breeding. Here we use the CRISPR-Cas9 system of genome editing[super...

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Bibliographic Details
Main Authors: Heckl, Dirk, Kowalczyk, Monika S., Yudovich, David, Belizaire, Roger, Puram, Rishi V., McConkey, Marie, Thielke, Anne, Aster, Jon C., Regev, Aviv, Ebert, Benjamin L.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/96710
https://orcid.org/0000-0001-8567-2049

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http://hdl.handle.net/1721.1/96710
https://orcid.org/0000-0001-8567-2049

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