Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive

Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR) signaling pathway, extends the life span of yeast, worms, flies, and mice. Interventions that promote longevity are often correlated with increased insulin sensitivity, and it therefore is surprising that chronic rapamycin treatme...

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Bibliographic Details
Main Authors: Lamming, Dudley W., Ye, Lan, Astle, Clinton M., Baur, Joseph A., Harrison, David E., Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Wiley Blackwell 2015
Online Access:http://hdl.handle.net/1721.1/96741
https://orcid.org/0000-0002-0079-4467
https://orcid.org/0000-0002-1446-7256