Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival

Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival

The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates organismal growth in response to many environmental cues, including nutrients and growth factors. Cell-based studies showed that mTORC1 senses amino acids through the RagA–D family of GTPases (also known as RRAGA, B, C and D),...

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Bibliographic Details
Main Authors: Efeyan, Alejo, Zoncu, Roberto, Chang, Steven, Gumper, Iwona, Snitkin, Harriet, Kirak, Oktay, Sabatini, David D., Wolfson, Rachel Laura, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/96745
https://orcid.org/0000-0002-9535-7664
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/96745
https://orcid.org/0000-0002-9535-7664
https://orcid.org/0000-0002-1446-7256

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