Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival
The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates organismal growth in response to many environmental cues, including nutrients and growth factors. Cell-based studies showed that mTORC1 senses amino acids through the RagA–D family of GTPases (also known as RRAGA, B, C and D),...
Main Authors: | Efeyan, Alejo, Zoncu, Roberto, Chang, Steven, Gumper, Iwona, Snitkin, Harriet, Kirak, Oktay, Sabatini, David D., Wolfson, Rachel Laura, Sabatini, David |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2015
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Online Access: | http://hdl.handle.net/1721.1/96745 https://orcid.org/0000-0002-9535-7664 https://orcid.org/0000-0002-1446-7256 |
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