Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

Caloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust interventions known to increase longevity in lower organisms. However, little is known about the molecular adaptations induced by CR in humans. Here, we report that long-term CR in humans inhibits the IGF-1/i...

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Bibliographic Details
Main Authors: Mercken, Evi M., Crosby, Seth D., Lamming, Dudley W., JeBailey, Lellean, Krzysik-Walker, Susan, Villareal, Dennis T., Capri, Miriam, Franceschi, Claudio, Zhang, Yongqing, Becker, Kevin, de Cabo, Rafael, Fontana, Luigi, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Wiley Blackwell 2015
Online Access:http://hdl.handle.net/1721.1/96746
https://orcid.org/0000-0002-0079-4467
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/96746
https://orcid.org/0000-0002-0079-4467
https://orcid.org/0000-0002-1446-7256

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