Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

By dividing asymmetrically, stem cells can generate two daughter cells with distinct fates. However, evidence is limited in mammalian systems for the selective apportioning of subcellular contents between daughters. We followed the fates of old and young organelles during the division of human mamma...

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Bibliographic Details
Main Authors: Chen, Walter W., Marjanovic, Nemanja, Zoncu, Roberto, Katajisto, Pekka, Dohla, Julia, Chaffer, Christine L., Pentinmikko, Nalle, Iqbal, Sharif, Weinberg, Robert A, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2015
Online Access:http://hdl.handle.net/1721.1/96748
https://orcid.org/0000-0002-0895-3557
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-1446-7256