Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

As the concentrations of highly consumed nutrients, particularly glucose, are generally lower in tumours than in normal tissues, cancer cells must adapt their metabolism to the tumour microenvironment. A better understanding of these adaptations might reveal cancer cell liabilities that can be explo...

Full description

Bibliographic Details
Main Authors: Possemato, Richard, Lorbeer, Franziska K., Bayraktar, Erol C., Thiru, Prathapan, Yucel, Burcu, Wang, Tim, Chen, Walter W., Clish, Clary, Birsoy, Kivanc, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/96757
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-2401-0030
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/96757
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-2401-0030
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-1446-7256

Similar Items