Rapamycin Doses Sufficient to Extend Lifespan Do Not Compromise Muscle Mitochondrial Content or Endurance

Rapamycin Doses Sufficient to Extend Lifespan Do Not Compromise Muscle Mitochondrial Content or Endurance

Rapamycin extends lifespan in mice, but can have a number of undesirable effects that may ultimately limit its utility in humans. The canonical target of rapamycin, and the one thought to account for its effects on lifespan, is the mammalian/mechanistic target of rapamycin, complex 1 (mTORC1). We ha...

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Bibliographic Details
Main Authors: Ye, Lan, Widlund, Anne L., Sims, Carrie A., Lamming, Dudley W., Guan, Yuxia, Davis, James G., Harrison, David E., Vang, Ole, Baur, Joseph A., Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Impact Journals 2015
Online Access:http://hdl.handle.net/1721.1/96763
https://orcid.org/0000-0002-0079-4467
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/96763
https://orcid.org/0000-0002-0079-4467
https://orcid.org/0000-0002-1446-7256

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