Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

mTOR is a highly conserved serine/threonine protein kinase that serves as a central regulator of cell growth, survival, and autophagy. Deregulation of the PI3K/Akt/mTOR signaling pathway occurs commonly in cancer and numerous inhibitors targeting the ATP-binding site of these kinases are currently u...

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Main Authors: Liu, Qingsong, Xu, Chunxiao, Kirubakaran, Sivapriya, Zhang, Xin, Hur, Wooyoung, Kwiatkowski, Nicholas P., Wang, Jinhua, Westover, Kenneth D., Gao, Peng, Ercan, Dalia, Niepel, Mario, Thoreen, Carson C., Kang, Seong A., Patricelli, Matthew P., Wang, Yuchuan, Tupper, Tanya, Altabef, Abigail, Kawamura, Hidemasa, Held, Kathryn D., Chou, Danny M., Elledge, Stephen J., Janne, Pasi A., Wong, Kwok-Kin, Gray, Nathanael S., Sabatini, David, Liu, Yan
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for Cancer Research 2015
Online Access:http://hdl.handle.net/1721.1/96764
https://orcid.org/0000-0002-1446-7256

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http://hdl.handle.net/1721.1/96764
https://orcid.org/0000-0002-1446-7256

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