CRISPR-mediated direct mutation of cancer genes in the mouse liver
The study of cancer genes in mouse models has traditionally relied on genetically-engineered strains made via transgenesis or gene targeting in embryonic stem cells. Here we describe a new method of cancer model generation using the CRISPR/Cas (clustered regularly interspaced short palindromic repea...
Main Authors: | , , , , , , , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2015
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Online Access: | http://hdl.handle.net/1721.1/96801 https://orcid.org/0000-0001-5785-8911 https://orcid.org/0000-0003-1465-1691 https://orcid.org/0000-0001-9587-0233 https://orcid.org/0000-0002-7045-7837 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0001-6898-3793 https://orcid.org/0000-0003-3675-6961 https://orcid.org/0000-0002-0460-8246 |
Internet
http://hdl.handle.net/1721.1/96801https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0001-9587-0233
https://orcid.org/0000-0002-7045-7837
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0001-6898-3793
https://orcid.org/0000-0003-3675-6961
https://orcid.org/0000-0002-0460-8246