CRISPR-mediated direct mutation of cancer genes in the mouse liver

CRISPR-mediated direct mutation of cancer genes in the mouse liver

The study of cancer genes in mouse models has traditionally relied on genetically-engineered strains made via transgenesis or gene targeting in embryonic stem cells. Here we describe a new method of cancer model generation using the CRISPR/Cas (clustered regularly interspaced short palindromic repea...

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Bibliographic Details
Main Authors:	Xue, Wen, Chen, Sidi, Yin, Hao, Tammela, Tuomas, Papagiannakopoulos, Thales, Cai, Wenxin, Bronson, Roderick T., Crowley, Denise G., Zhang, Feng, Sharp, Phillip A., Joshi, Nik, Yang, Gillian R., Anderson, Daniel Griffith, Jacks, Tyler E
Other Authors:	Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format:	Article
Language:	en_US
Published:	Nature Publishing Group 2015
Online Access:	http://hdl.handle.net/1721.1/96801 https://orcid.org/0000-0001-5785-8911 https://orcid.org/0000-0003-1465-1691 https://orcid.org/0000-0001-9587-0233 https://orcid.org/0000-0002-7045-7837 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0001-6898-3793 https://orcid.org/0000-0003-3675-6961 https://orcid.org/0000-0002-0460-8246

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