Target specificity of the CRISPR-Cas9 system
The CRISPR-Cas9 system, naturally a defense mechanism in prokaryotes, has been repurposed as an RNA-guided DNA targeting platform. It has been widely used for genome editing and transcriptome modulation, and has shown great promise in correcting mutations in human genetic diseases. Off-target effect...
| Main Authors: | , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Springer-Verlag
2015
|
| Online Access: | http://hdl.handle.net/1721.1/96803 https://orcid.org/0000-0003-1465-1691 https://orcid.org/0000-0003-0369-5269 |