Elevated circulating branched chain amino acids are an early event in pancreatic adenocarcinoma development

Most patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed with advanced disease and survive less than 12 months. PDAC has been linked with obesity and glucose intolerance, but whether changes in circulating metabolites are associated with early cancer progression is unknown. To better...

Full description

Bibliographic Details
Main Authors: Mayers, Jared R., Torrence, Margaret E., Fiske, Brian Prescott, Davidson, Shawn Michael, Papagiannakopoulos, Thales, Dayton, Talya Lucia, Vander Heiden, Matthew G.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/96828
https://orcid.org/0000-0002-8607-1787
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0001-9587-0233
https://orcid.org/0000-0003-0701-5275
https://orcid.org/0000-0002-7994-7963