Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Tumour oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state, but direct pharmacological inhibition of transcription factors has so far proven difficult. However, the transcriptional machinery contains various enzymatic cofactors tha...

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Bibliographic Details
Main Authors: Kwiatkowski, Nicholas P., Zhang, Tinghu, Rahl, Peter B., Abraham, Brian J., Reddy, Jessica, Ficarro, Scott B., Dastur, Anahita, Amzallag, Arnaud, Ramaswamy, Sridhar, Tesar, Bethany, Jenkins, Catherine E., Hannett, Nancy M., McMillin, Douglas, Sanda, Takaomi, Sim, Taebo, Kim, Nam Doo, Look, A. Thomas, Mitsiades, Constantine S., Weng, Andrew P., Brown, Jennifer R., Benes, Cyril H., Marto, Jarrod A., Young, Richard A., Gray, Nathanael S.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2015
Online Access:http://hdl.handle.net/1721.1/96851
https://orcid.org/0000-0002-2171-9394
https://orcid.org/0000-0001-8855-8647

Internet

http://hdl.handle.net/1721.1/96851
https://orcid.org/0000-0002-2171-9394
https://orcid.org/0000-0001-8855-8647

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