Long-Term Seizure Suppression and Optogenetic Analyses of Synaptic Connectivity in Epileptic Mice with Hippocampal Grafts of GABAergic Interneurons

Long-Term Seizure Suppression and Optogenetic Analyses of Synaptic Connectivity in Epileptic Mice with Hippocampal Grafts of GABAergic Interneurons

Studies in rodent epilepsy models suggest that GABAergic interneuron progenitor grafts can reduce hyperexcitability and seizures in temporal lobe epilepsy (TLE). Although integration of the transplanted cells has been proposed as the underlying mechanism for these disease-modifying effects, prior st...

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Bibliographic Details
Main Authors: Henderson, K. W., Gupta, J., Litvina, E., Zheng, X., Van Zandt, M. A., Woods, N., Grund, E., Lin, D., Royston, S., Yanagawa, Y., Aaron, G. B., Naegele, J. R., Tagliatela, Stephanie
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Society for Neuroscience 2015
Online Access:http://hdl.handle.net/1721.1/96902

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http://hdl.handle.net/1721.1/96902

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