Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused 3D human liver bioreactor

Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused 3D human liver bioreactor

Endotoxin lipopolysaccharide (LPS) is known to cause liver injury primarily involving inflammatory cells such as Kupffer cells, but few in vitro culture models are applicable for investigation of inflammatory effects on drug metabolism. We have developed a 3D human microphysiological hepatocyte-Kupf...

Full description

Bibliographic Details
Main Authors: Sarkar, Ujjal, Rivera-Burgos, Dinelia, Large, Emma M., Hughes, David J., Kodihalli, Ravindra, Dyer, Rachel Lee, Ebrahimkhani, Mohammad Reza, Wishnok, John S., Griffith, Linda G., Tannenbaum, Steven Robert
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Society for Pharmacology & Experimental Therapeutics (ASPET) 2015
Online Access:http://hdl.handle.net/1721.1/96927
https://orcid.org/0000-0002-1801-5548
https://orcid.org/0000-0002-2325-552X
https://orcid.org/0000-0002-9618-8495

Internet

http://hdl.handle.net/1721.1/96927
https://orcid.org/0000-0002-1801-5548
https://orcid.org/0000-0002-2325-552X
https://orcid.org/0000-0002-9618-8495

Similar Items